A midwife by trade, Madame Loretta has a secret surrogacy business specializing in selling fair complexion babies to an elite clientele, but when one of her gurls delivers an albino chold into laye 1800s rural Louisiana's very superstitious and colorist soci, everything Madame Lorettas has built may come crashing down. With themes of colorism, racism, religious syncretism, and the relationship between parent and child, Madame Loretta's Girls is mysterious, dark, and intriguing.